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Basilar artery atherosclerotic disease is related to subacute lesion volume increase in pontine base infarction

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Author(s)
조경희
Alternative Author(s)
Cho, Kyung Hee
Publication Year
2009
Abstract
Background – Although b asilar artery atherosclerotic disease (BAD)
is frequent in patients with pontine base infarction, it remains
unknown whether BAD is related to the lesion size or clinical
outcome. Methods – We studied 56 patients with unilateral pontine
base infarction who underwent (i) diffusion-weighted MRI within 4 8 h
after stroke onset and (ii) follow-up MRI and MR angiography in the
subacute stage. Neurologic progression was defined as increased
National Institutes of Health Stroke Scale score by ‡ 2 during
admission. Clinical outcome was dichotomized as good and poor (‡ 3)
according to the modified Rankin Scale at 1 month a fter stroke
onset. Results – Twenty-t wo patients (39%) had BAD and 15 pat ients
(27%) had neurologic progression. Follow-up MRI performed at
median 3.5  1.1 days after the initial MRI showed the lesion
volume significantly increased (P < 0.001). The BAD was not
significantly related to demographic characteristics, risk factors, i nitial
and f ollow-up lesion volume, neurologic progression and clinical
outcome, but was closely related to the subacute increase in lesion
volume (P = 0.004 for 20% increase, P = 0.029 for 50%
increase). Conclusions – BAD is related to subacute increase in lesion
volume, but not to ultimate poor clinical outcome in patients with
pontine base infarction.
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
Acta Neurologica Scandinavica, Vol.120(2) : 88-93, 2009
Type
Article
ISSN
0001-6314
DOI
10.1111/j.1600-0404.2008.01124.x
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34853
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