Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas

Authors
DONG CHOON KIMWOO JIN CHUNGJAE-HO LEEBYUNG KUK JANGJAE SEOK HWANGKOO JEONG KANGSUN YOUNG KWON
Department
Dept. of Internal Medicine (내과학); Dept. of Anatomy (해부학); Dept. of Surgery (외과학); Dept. of Pathology (병리학)
Issue Date
2014
Citation
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol.122(10) : 1001-1006, 2014
ISSN
0903-4641
Abstract
Kim DC, Chung WJ, Lee J-H, Jang BK, Hwang JS, Kang KJ, Kwon SY. Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas. APMIS 2014; 122: 1001–1006. Hepatocellular carcinoma (HCC) is the fourth most common form of cancer in the Korean population, caused primarily by infection with either the Hepatitis B or C virus. Progression of this disease is frequently associated with mutations in either phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) or hepatitis B virus X (HBx) gene. Previous studies have examined the frequency of PIK3CA mutations in HCC, although the clinical significance of these mutations has not been studied in a Korean population. In addition, HBx appears to play a key role in modulating a wide range of cellular functions, leading to HCC. In this study, we examined microdissected tumor samples from 50 HCC patients who underwent hepatectomy at Keimyung University Dongsan Medical Center. These patients were screened for mutations in PIK3CA and HBx to identify the clinical outcomes associated with these mutations. Exons 9 and 20 of PIK3CA and the entirety of HBx were screened for mutations by polymerase chain reaction and direct DNA sequencing. PIK3CA mutations were detected in 7 of 50 patients (14%). Among the 42 patients who were seropositive for hepatitis B, 17 (40.5%) had HBx mutations and 4 (9.52%) had mutations in PIK3CA. PIK3CA mutations were strongly correlated with tumor size. Patients harboring HBx mutations exhibited a longer time to recurrence; this difference was statistically significant not only in comparison with the PIK3CA mutation but also compared with those without any mutations. This result suggests a role for PIK3CA and HBx mutations as prognostic markers in HCC. Key words: PIK3CA; HBx; hepatocellular carcinoma; mutation. Woo Jin Chung, Department of Internal Medicine, Keimyung University Dongsan Medical Center, 56 Dalsung-ro, Jung-gu, Daegu 700-712, Korea. e-mail: chung50@dsmc.or.kr
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34858
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
Keimyung Author(s)
정우진; 장병국; 황재석; 이재호; 강구정; 권선영
Full Text
http://dx.doi.org.proxy.dsmc.or.kr/10.1111/apm.12245
File in this Item
 사서에게 요청하기
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE