Clinicopathological characteristics of PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas
- 정우진; 장병국; 황재석; 이재호; 강구정; 권선영
- Alternative Author(s)
- Chung, Woo Jin; Jang, Byoung Kuk; Hwang, Jae Seok; Lee, Jae Ho; Kang, Koo Jeong; Kwon, Sun Young
- Publication Year
- Kim DC, Chung WJ, Lee J-H, Jang BK, Hwang JS, Kang KJ, Kwon SY. Clinicopathological characteristics of
PIK3CA and HBx mutations in Korean patients with hepatocellular carcinomas. APMIS 2014; 122: 1001–1006.
Hepatocellular carcinoma (HCC) is the fourth most common form of cancer in the Korean population, caused primarily
by infection with either the Hepatitis B or C virus. Progression of this disease is frequently associated with mutations
in either phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) or hepatitis B virus X (HBx) gene. Previous studies
have examined the frequency of PIK3CA mutations in HCC, although the clinical significance of these mutations has
not been studied in a Korean population. In addition, HBx appears to play a key role in modulating a wide range of
cellular functions, leading to HCC. In this study, we examined microdissected tumor samples from 50 HCC patients
who underwent hepatectomy at Keimyung University Dongsan Medical Center. These patients were screened for mutations
in PIK3CA and HBx to identify the clinical outcomes associated with these mutations. Exons 9 and 20 of
PIK3CA and the entirety of HBx were screened for mutations by polymerase chain reaction and direct DNA sequencing.
PIK3CA mutations were detected in 7 of 50 patients (14%). Among the 42 patients who were seropositive for hepatitis
B, 17 (40.5%) had HBx mutations and 4 (9.52%) had mutations in PIK3CA. PIK3CA mutations were strongly
correlated with tumor size. Patients harboring HBx mutations exhibited a longer time to recurrence; this difference was
statistically significant not only in comparison with the PIK3CA mutation but also compared with those without any
mutations. This result suggests a role for PIK3CA and HBx mutations as prognostic markers in HCC.
Key words: PIK3CA; HBx; hepatocellular carcinoma; mutation.
Woo Jin Chung, Department of Internal Medicine, Keimyung University Dongsan Medical Center, 56 Dalsung-ro,
Jung-gu, Daegu 700-712, Korea. e-mail: firstname.lastname@example.org
- 공개 및 라이선스
- Files in This Item:
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.