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Ultrasonographic detection and characterization of asymptomatic ductal carcinoma in situ with histopathologic correlation

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Author(s)
이상권
Alternative Author(s)
Lee, Sang Kwon
Publication Year
2011
Abstract
Background: Most ductal carcinoma in situ (DCIS) of the breast is asymptomatic and usually manifests as
calcifications in screening mammography. On the other hand, little is known about ultrasonographic (US)
features of asymptomatic DCIS, for US is rarely used for the diagnosis and evaluation of DCIS because of
low sensitivity in detecting microcalcifications.
Purpose: To evaluate US detection and characterization of DCIS in asymptomatic women and correlate
these imaging findings with the histopathologic features.
Material and Methods: This retrospective study evaluated mammographic and US images of 60 DCIS cases
from 59 asymptomatic women. US was performed in knowledge of mammographic findings. The
following histopathologic parameters were analyzed: Van Nuys classification, architectural pattern, and
presence of microinvasion. Image detectability and US features were correlated with these histopathologic
parameters.
Results: Of the 54 cases (90.0%) detected on mammography, 48 cases (88.9%) had microcalcifications only,
5 (9.3%) had microcalcifications with associated density, and 1 (1.9%) had soft tissue density alone. Of the
38 cases (63.3%) identified by US, 29 cases (76.3%) had a mass with or without microcalcifications, six
(15.8%) had microcalcifications only, and three (7.9%) had other findings. US identified lesions were
associated with higher Van Nuys groups, microinvasion and comedocarcinoma (P ¼ 0.044, P ¼ 0.024, and
P ¼ 0.032, respectively). The most common US finding was a not-circumscribed, oval mass with parallel
orientation and normal acoustic transmission. Microcalcifications were seen on US in 31 (81.6%) of the 38
US visible cases; this finding showed a trend of association with Van Nuys group 2 and 3 but was not
statistically significant (P ¼ 0.063).
Conclusion: When DCIS was identified on US, it was associated with more aggressive histopathologic
type. However, mammographic correlation is essential to differentiate benign from malignant lesion in cases
seen by US; US findings of asymptomatic DCIS had a low suspicion of malignancy.
Keywords: Breast, ultrasound, screening, neoplasms, calcifications
Department
Dept. of Radiology (영상의학)
Publisher
School of Medicine
Citation
Acta Radiologica, Vol.52(4) : 364-371, 2011
Type
Article
ISSN
0284-1851
DOI
10.1258/ar.2011.100391
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34863
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