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Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three-Dimensional Extracellular Matrix

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Author(s)
허윤석
Alternative Author(s)
Heo, Yun Seok
Publication Year
2014
Abstract
Neural stem cells (NSCs) reside in a vascular microenvironment termed the
“NSC niche.” Blood vessels in the NSC niche play an important role in maintaining
an appropriate balance between NSC self-renewal and differentiation
that serves to maintain homeostasis. Understanding the role of brain vessels
in the NSC niche will facilitate basic research in neurogenesis and vasculogenesis
as well as aid the development of potential therapies for degenerative
disorders. Here, an in vitro-reconstituted NSC-vascular niche consisting of a
3D brain vasculature and extracellular matrix (ECM) microenvironment that
allows NSCs to adopt physiologically relevant phenotypes through the combined
effects of ECM components, chemical gradients, and signaling effectors
from the brain vasculature is described. The reconstituted niche can provide
precise spatiotemporal control of the NSC niche, regulating self-renewal, proliferation
and colony formation of NSCs, and suppressing neuronal generation
but promoting NSC differentiation into astrocytes and oligodendrocytes.
It is proved that Notch effectors regulate both the astrocyte differentiation
and NSC self-renewal, but the astrocyte differentiation is more active in NSCs
in close proximity to brain vasculature. A potential role of the other vascular
microenvironmental factor of pigment epithelium-derived factor from brain
vasculature in the regulation of NSC self-renewal is also proved.
Department
Dept. of Biomedical Engineering (의용공학과)
Publisher
School of Medicine
Citation
Advanced Healthcare Materials, Vol.3(9) : 1457-1464, 2014
Type
Article
ISSN
2192-2640
DOI
10.1002/adhm.201300569
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34865
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