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Green Tea Extract Co-administered with a Polymer Effectively Prevents Alcoholic Liver Damage by Prolonged Inhibition of Alcohol Absorption in Mice.

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Author(s)
박재형배재훈송대규황일선배기철
Alternative Author(s)
Park, Jae HyungBae, Jae HoonSong, Dae KyuHwang, Il SeonBae, Ki Cheor
Publication Year
2013
Abstract
Aims: Alcohol toxicity can induce multiple organ dysfunction, including the liver. Gallated catechins (GCs), the components
of green tea extract (GTE), have been known to inhibit intestinal lipid absorption. This study was designed to investigate the inhibitory
effect of GC on the absorption of the lipid-soluble ethanol in normal mice. In addition, the effectiveness of prolonging the
GC-mediated effect was evaluated as a means of preventing alcoholic liver damage. Methods: GTE was administered orally immediately
or 90 min before ethanol administration and the blood ethanol and acetaldehyde levels were measured. Binge ethanol administration
(by gavage every 6 h for 24 h) was used to induce acute liver injury, and GTE was administered 90 min prior to every ethanol
administration. Results: When GTE, but not GC-decreased GTE, was administered immediately before ethanol intake, the blood
ethanol and acetaldehyde levels were significantly lower than those in the control. On the other hand, GTE has no effect when GTE
was administered 90 min before ethanol intake. When GTE was co-administered with polyethylene glycol (PEG) or poly-γ-glutamate
(PGA) 90 min before ethanol intake, the lowering effect of GTE on the blood ethanol and acetaldehyde levels was maintained in contrast
to the GTE-alone-treated group. After binge ethanol administration, liver weight decreased, and serum alanine aminotransferase
and aspartate aminotransferase levels were elevated. Additionally, histopathological changes, such as macrovesicular steatosis and necrosis,
were induced in the liver, together with reactive oxygen species generation. When GTE + PEG or GTE + PGA, but not GTE
alone, was administered 90 min before ethanol intake, acute liver injury was ameliorated. Conclusion: These findings support the development
of GTE + PEG or GTE + PGA as an inhibitor of intestinal alcohol absorption for the preventative treatment of acute
alcohol toxicity.
Department
Dept. of Physiology (생리학)
Dept. of Pathology (병리학)
Dept. of Orthopedic Surgery (정형외과학)
Publisher
School of Medicine
Citation
Alcohol and Alcoholism, Vol.48(1) : 59-67, 2013
Type
Article
ISSN
0735-0414
DOI
10.1093/alcalc/ags118
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34878
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