Comparison of Inravascular Ultrasound and Histological Findings in Culprit Coronary Plaques Between ST-Segment Elevation and Non-ST-Segment Elevation Myocardial Infarction

Authors
Cheol Whan LeeIlseon HwangChan-Sik ParkHyangsin LeeDuk-Woo ParkSoo-Jin KangSeung-Whan LeeYoung-Hak KimSeong-Wook ParkSeung-Jung Park
Department
Dept. of Pathology (병리학)
Issue Date
2013
Citation
American Journal of Cardiology, Vol.112(1) : 68-72, 2013
ISSN
0002-9149
Abstract
It remains uncertain whether the histology of culprit coronary plaques differs between ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI). We compared intravascular ultrasound (IVUS) and histologic findings in coronary culprit plaques among patients presenting with STEMI and NSTEMI. Atherectomy specimens were obtained from 96 patients, 70 with STEMI and 26 with NSTEMI, who underwent directional coronary atherectomy for de novo coronary artery lesions. IVUS examinations were performed before directional coronary atherectomy. IVUS and histologic data were analyzed. Clinical characteristics were largely similar between the 2 groups; however, normal antegrade flow before angioplasty was less frequently observed in patients with STEMI than those with NSTEMI. Plaque rupture was more common on the proximal side of the minimal lumen site. There were no differences in vessel area, lumen area, calcification, plaque burden, or remodelling index at the reference and culprit sites. However, the arc of the ruptured cavity was significantly greater in patients with STEMI than those with NSTEMI (69.4 – 27.9 vs 51.8 – 20.0 , respectively, p [ 0.008). The proportion of atheroma, fibrocellular, and thrombus areas was not different between the 2 groups. Similarly, the relative areas immunopositive for CD31, smooth muscle a-actin, and CD68 were similar in the 2 groups. In conclusion, coronary culprit lesions in patients with STEMI show more severe plaque rupture with similar histologic features than those in patients with NSTEMI, supporting the idea that a large plaque rupture is more likely in STEMI patients. 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;112:68e72)
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34888
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
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Full Text
https://linkinghub.elsevier.com/retrieve/pii/S0002914913007054
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