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Familial Benign Recurrent Vertigo

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Author(s)
Andrew K. OhHyung LeeJoanna C. JenSonia CoronaKathleen M. JacobsonRobert W. Baloh
Publication Year
2001
Abstract
Benign recurrent vertigo (BRV) has been
previously linked to migraine but there
have been no prior studies of families with
BRV. We studied the families of 24 patients
who presented to our clinic with BRV and
who reported a family history of similar
attacks of vertigo. All probands underwent
diagnostic evaluation to exclude identi®-
able causes of recurrent vertigo and they
completed a standardized medical question-
naire pertaining to episodic vertigo and the
features of migraine. This questionnaire
was also sent to all relatives of the probands
who agreed to participate. Of 220 relatives
who returned questionnaires, 37% reported
BRV and 50% met the diagnostic criteria for
migraine. By contrast, only one of 43 (2%)
unrelated spouses reported BRV and 10 of 43
(23%) met the diagnostic criteria for
migraine. More than two-thirds of relatives
with BRV met the diagnostic criteria for
migraine and the majority reported that
they had a typical migraine headache with
at least some of their episodes of vertigo.
Both BRV and migraine showed a female
preponderance (more than 2 to 1). Familial
BRV seems to be a migraine syndrome,
probably inherited in an autosomal domi-
nant fashion with decreased penetrance in
men. In the search for the causative gene,
vertigo may be a more useful marker than
migraine because recurrent vertigo is rela-
tively rare in the general population where-
as migraine is very common.
ß 2001 Wiley-Liss, Inc.
KEY WORDS: migraine; vertigo; genes
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
American Journal of Medical Genetics, Vol.100(4) : 287-291, 2001
Type
Article
ISSN
1552-4825
DOI
10.1002/ajmg.1294
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34906
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