Comparison of vascular response to zotarolimus-eluting stent versus sirolimus-eluting stent: Intravascular ultrasound results from ENDEAVOR III

Akiyoshi MiyazawaJunya AkoYoichiro HongoSeung-Ho HurIchizo TsujinoBrian K. CourtneyAli H.M. HassanDavid E. KandzariYasuhiro HondaPeter J. Fitzgerald
Dept. of Internal Medicine (내과학)
Issue Date
American Heart Journal, Vol.155(1) : 108-113, 2008
Background The purpose of this study was to investigate the vascular response of zotarolimus-eluting stent (ZES) and sirolimus-eluting stent (SES) using serial intravascular ultrasound (IVUS). Methods Data were obtained from the Endeavor Drug-Eluting Coronary Stent System Versus the Center Siromlimus- Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions (ENDEAVOR) III trial, a randomized study comparing ZES and SES for the treatment of de novo native coronary artery lesions. Serial (baseline and 8-month follow-up) IVUS was available in 258 patients (190 ZES, 68 SES). Results At 8 months, ZES had greater percentage of neointimal volume index (ZES 1.1 ± 0.8 mm3/mm vs SES 0.2 ± 0.1 mm3/mm, P b .01), resulting in smaller lumen volume index (6.0 ± 2.0 mm3/mm vs 7.0 ± 2.1 mm3/mm, P b .05). Zotarolimus-eluting stents showed larger IVUS-detectable neointimal coverage over stent surface (50.2% vs 10.5%, P b .01) and greater mean neointimal thickness (0.19 ± 0.07 mm vs 0.10 ± 0.06 mm, P b .01). Zotarolimus-eluting stents had a significantly lower incidence of late-acquired incomplete stent apposition. Conclusions Zotarolimus-eluting stent is associated with a significantly greater amount of neointimal hyperplasia compared with SES. This amount of hyperplasia in ZES is distributed throughout the stent at 8-month follow-up. (Am Heart J 2008;155:108-13.)
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