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Genome-wide single-nucleotide polymorphism-array based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment

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Affiliated Author(s)
도영록
Alternative Author(s)
Do, Young Rok
Journal Title
Annals of Hematology
ISSN
0939-5555
Issued Date
2013
Abstract
Decitabine is a hypomethylating agent with proven
clinical efficacy in myelodysplastic syndrome (MDS). The
current study analyzed the role of single nucleotide polymorphism
array (SNP-A)-based karyotyping in prediction of
clinical outcome in MDS or chronic myelomonocytic leukemia
(CMML) patients following decitabine therapy. A total of
61 MDS/CMML patients treated with decitabine were evaluated
with Genome-Wide Human SNP 6.0 Array using DNAsderived from marrow samples. The primary endpoint was the
best response rate including complete (CR) and partial response
(PR) with overall (OS) and event-free survival (EFS)
as secondary endpoints. Best response was noted in 14
patients (26.4 %) out of 53 evaluated patients including 12
CR and two PR with median follow-up of 21.6 months. A
total of 81 abnormal SNP lesions were found in 25 out of 61
patients (41.0%). The patients carrying abnormal SNP lesions
showed an inferior CR/PR rate (p00.002) and showed a trend
of worse OS (p00.02 in univariate, p00.09 in multivariate)
compared to those without SNP lesions, but not were associated
with inferior EFS. The presence of abnormal SNP lesions
in MDS was associated with adverse outcomes following
decitabine therapy. Further study is strongly warranted to
establish the role of SNP-A karyotyping in MDS.
Keywords Myelodysplastic syndrome . Chronic
monomyelocytic leukemia . Single nucleotide
polymorphism-based karyotyping . Copy number
alterations . Copy neutral loss of heterozygosity (CN-LOH)
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Kyoung Ha Kim et al. (2013). Genome-wide single-nucleotide polymorphism-array based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment. Annals of Hematology, 92(4), 459–69. doi: 10.1007/s00277-012-1635-7
Type
Article
ISSN
0939-5555
DOI
10.1007/s00277-012-1635-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34970
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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