Low incidence of clinically apparent thromboembolism in Korean patients with multiple myeloma treated with thalidomide

Authors
Youngil KohSoo-Mee BangJae Hoon LeeHwi-Joong YoonYoung-Rok DoHun-Mo RyooNari LeeSeok Jin KimKihyun KimSung-Soo YoonJong-Ho WonYeung-Chul MunMoon-Hee LeeKi-Hyun RheeHyo-Jung KimHyeonSeok EomMin Kyoung KimHyun Chun Shin
Department
Dept. of Internal Medicine (내과학)
Issue Date
2010
Citation
Annals of Hematology, Vol.89(2) : 201-206, 2010
ISSN
0939-5555
Abstract
The frequency of thromboembolic events (TE) in Caucasian patients with multiple myeloma (MM) receiving thalidomide as the initial treatment has been reported to be 10~58% without prophylactic anticoagulation. Korean MM patients treated with thalidomide were studied to determine the frequency of TE and associated risk factors. A retrospective medical record review of the Korean MM registry from 25 centers in Korea between 2003 and 2007was performed. We assessed the incidence of arterial and venous TE and the associated clinical parameters. Three hundred and sixty MM patients (median age 61 years, range 32–88 years) received thalidomide treatment. Fourteen patients (3.9%) developed TE: 12 had venous and two had arterial locations. The sites for the venous TE included lungs (seven), lower extremities (four), upper extremities (one), and neck (one). Arterial TE developed in cerebral and peripheral arteries each. No single clinical parameter such as prerequisite for the metabolic syndrome, disease status, and treatment regimen were predictive for the development of TE. The frequency of TE in patients who received thalidomide as initial therapy (7/155) was not different from those who received thalidomide for progressive or relapsed disease (7/205, p=0.592). The frequency of TE during thalidomide treatment in Korean patients with MM was low. No significant clinical factor was found to be a risk factor. The subgroup requiring thromboprophylaxis among the Korean patients with MM, receiving thalidomide, needs to be clarified. Keywords Multiple myeloma . Thalidomide . Thromboembolism
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34972
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
도영록
Full Text
https://link.springer.com/article/10.1007%2Fs00277-009-0807-6
File in this Item
 사서에게 요청하기
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE