계명대학교 의학도서관 Repository

Leptomeningeal Collaterals Are Associated with Modifiable Metabolic Risk Factors

Metadata Downloads
Affiliated Author(s)
장혁원홍정호손성일
Alternative Author(s)
Chang, Hyuk WonHong, Jeong HoSohn, Sung Il
Journal Title
Annals of Neurology
ISSN
0364-5134
Issued Date
2013
Abstract
Objective: We sought to identify potentially modifiable determinants associated with variability in leptomeningeal
collateral status in patients with acute ischemic stroke.
Methods: Data are from the Keimyung Stroke Registry. Consecutive patients with M1 segment middle cerebral arter-
y 6 intracranial internal carotid artery occlusions on baseline computed tomographic angiography (CTA) from May
2004 to July 2009 were included. Baseline and follow-up imaging was analyzed blinded to all clinical information.
Two raters assessed leptomeningeal collaterals on baseline CTA by consensus, using a previously validated regional
leptomeningeal score (rLMC).
Results: Baseline characteristics (N 5 206) were: mean age 5 66.9 6 11.6 years, median baseline National Institutes
of Health Stroke Scale 5 14 (interquartile range [IQR] 5 11–20), and median time from stroke symptom onset to
CTA 5 166 minutes (IQR 5 96–262). Poor collateral status at baseline (rLMC score 5 0–10) was seen in 73 of 206
patients (35.4%). On univariate analyses, patients with poor collateral status at baseline were older; were hyperten-
sive; had higher white blood cell count, blood glucose, D-dimer, and serum uric acid levels; and were more likely to
have metabolic syndrome. Multivariate modeling identified metabolic syndrome (odds ratio [OR] 5 3.22, 95% confi-
dence interval [CI] 5 1.69–6.15, p < 0.001), hyperuricemia (per 1mg/dl serum uric acid; OR 5 1.35, 95% CI 5 1.12–
1.62, p < 0.01), and older age (per 10 years; OR 5 1.34, 95% CI 5 1.02–1.77, p 5 0.03) as independent predictors
of poor leptomeningeal collateral status at baseline.
Interpretation: Metabolic syndrome, hyperuricemia, and age are associated with poor leptomeningeal collateral sta-
tus in patients with acute ischemic stroke.
Department
Dept. of Radiology (영상의학)
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
Bijoy K. Menon et al. (2013). Leptomeningeal Collaterals Are Associated with Modifiable Metabolic Risk Factors. Annals of Neurology, 74(2), 241–248. doi: 10.1002/ana.23906
Type
Article
ISSN
0364-5134
DOI
10.1002/ana.23906
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35009
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.