Randomized, Sham Controlled Trial of Transcranial Direct Current Stimulation for Painful Diabetic Polyneuropathy

Yon Joon KimJeonghun KuHyun Jung KimDal Jae ImHye Sun LeeKyung Ah HanYoun Joo Kang
Dept. of Biomedical Engineering (의용공학과)
Issue Date
Annals of Rehabilitation Medicine, Vol.37(6) : 766-776, 2013
Objective To investigate the analgesic effect of transcranial direct current stimulation (tDCS) over the primary motor (M1), dorsolateral prefrontal cortex (DLPFC), and sham tDCS in patients with painful diabetic polyneuropathy (PDPN). Methods Patients with PDPN (n=60) were divided randomly into the three groups (n=20 per group). Each group received anodal tDCS with the anode centered over the left M1, DLPFC, or sham stimulation for 20 minutes at intensity of 2 mA for 5 consecutive days. A blinded physician rated the patients’ pain using a visual analog scale (VAS), Clinical Global Impression (CGI) score, anxiety score, sleep quality, Beck Depression Inventory (BDI), and the pain threshold (PT) to pressure. Results After the tDCS sessions, the M1 group showed a significantly greater reduction in VAS for pain and PT versus the sham and DLPFC groups (p<0.001). The reduction in VAS for pain was sustained after 2 and 4 weeks of follow-up in the M1 group compared with the sham group (p<0.001, p=0.007). Significant differences were observed among the three groups over time in VAS for pain (p<0.001), CGI score (p=0.01), and PT (p<0.001). No significant difference was observed among the groups in sleep quality, anxiety score, or BDI score immediately after tDCS. Conclusion Five daily sessions of tDCS over the M1 can produce immediate pain relief, and relief 2- and 4-week in duration in patients with PDPN. Our findings provide the first evidence of a beneficial effect of tDCS on PDPN. Keywords Transcranial direct current stimulation, Chronic pain, Diabetic neuropathy Annals of Rehabilitation Medicine Original Article Ann Rehabil Med 2013;37(6):
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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