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Role of Systematic Lymphadenectomy and Adjuvant Radiation in Early-Stage Endometrioid Uterine Cancer

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Author(s)
조치흠
Alternative Author(s)
Cho, Chi Heum
Publication Year
2010
Abstract
Objective. To determine the roles of lymphadenectomy in
endometrioid uterine cancer patients and adjuvant radiation
in early-stage endometrioid uterine cancer patients who
underwent systematic lymphadenectomy.
Methods. A retrospective analysis of 758 patients surgically
treated for early-stage endometrioid uterine cancer
from 2000 to 2006 was conducted. The primary outcome
was 5-year overall survival in relation to systematic lymphadenectomy
with or without adjuvant radiation.
Results. Of the 758 patients, 547 (72.2%) underwent
complete surgical staging, including systematic lymphadenectomy;
adjuvant radiation was administered to 207
patients (27.3%). Within median follow-up of 35 months,
systematic lymphadenectomy did not affect overall survival
in early-stage patients (P = 0.4480). In the high-risk,
early-stage group, however, the 5-year survival rate of the
systematic lymphadenectomy group showed better survival
compared with the no systematic lymphadenectomy group
(P = 0.0095). Also, adjuvant radiation did not affect
overall survival in early-stage patients (P = 0.1170), even
in the group of high-risk, early-stage patients (P = 0.5680)
who underwent systematic lymphadenectomy.
Conclusions. Systematic lymphadenectomy provided a
survival benefit in high-risk endometrioid uterine cancer
patients. However, in patients who underwent systematic
lymphadenectomy, adjuvant radiation was not beneficial,
even in high-risk patients.
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Publisher
School of Medicine
Citation
Annals of Surgical Oncology, Vol.17(11) : 2951-2957, 2010
Type
Article
ISSN
1068-9256
DOI
10.1245/s10434-010-1169-y
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35044
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