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No microsatellite instability using Bethesda panel and revised markers in uterine leiomyomas

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Author(s)
이재호김대광
Alternative Author(s)
Lee, Jae HoKim, Dae Kwang
Publication Year
2014
Abstract
Uterine leiomyomas are benign tumors of the uterus that arise clonally from smooth muscle cells of the myometrium
and are very common reason for hysterectomy. The aim of this study was to evaluate microsatellite instability (MSI) in
uterine leiomyomas using a set of MSI markers by Promega Corporation (Madison, WI, USA) and the Bethesda guide-
line. DNA was isolated from paired normal and tumoral tissues in 50 patients with uterine leiomyomas and MSI was
analyzed by using seven microsatellite markers. Our result showed that microsatellite stability was found in all uterine
leiomyomas. These data confirm the genetic status of uterine leiomyomas for the first time in Korean populations, and
suggest that uterine leiomyomas have genetic stability in Korean.
Key words: Uterine leiomyomas; microsatellite instability; genetic instability.
Department
Dept. of Anatomy (해부학)
Dept. of Medical Genetics(의학유전학)
Institute for Medical Science (의과학연구소)
Publisher
School of Medicine
Citation
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol.122(1) : 1-4, 2014
Type
Article
ISSN
0903-4641
DOI
10.1111/apm.12232
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35068
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