No microsatellite instability using Bethesda panel and revised markers in uterine leiomyomas
- 이재호; 김대광
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- Lee, Jae Ho; Kim, Dae Kwang
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- Uterine leiomyomas are benign tumors of the uterus that arise clonally from smooth muscle cells of the myometrium
and are very common reason for hysterectomy. The aim of this study was to evaluate microsatellite instability (MSI) in
uterine leiomyomas using a set of MSI markers by Promega Corporation (Madison, WI, USA) and the Bethesda guide-
line. DNA was isolated from paired normal and tumoral tissues in 50 patients with uterine leiomyomas and MSI was
analyzed by using seven microsatellite markers. Our result showed that microsatellite stability was found in all uterine
leiomyomas. These data conﬁrm the genetic status of uterine leiomyomas for the ﬁrst time in Korean populations, and
suggest that uterine leiomyomas have genetic stability in Korean.
Key words: Uterine leiomyomas; microsatellite instability; genetic instability.
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