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Decaffeinated coffee prevents scopolamine-induced memory impairment in rats

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Affiliated Author(s)
장정희
Alternative Author(s)
Jang, Jung Hee
Journal Title
Behavioural Brain Research
ISSN
0166-4328
Issued Date
2013
Abstract
Introduction: Several human studies have reported that coffee consumption improves cognitive performance.
In the present study, we investigated whether instant decaffeinated coffee also ameliorates
cognitive performance and attenuates the detrimental effects of scopolamine on memory.
Methods: Memory performance was evaluated in Morris water maze test and passive avoidance test.
Instant decaffeinated coffee (p.o.) at 120 or 240 mg/kg in Sprague-Dawley rats, which is equivalent to
approximately three or six cups of coffee, respectively, in a 60 kg human, was administered for two
weeks.
Results: Oral gavage administration of instant decaffeinated coffee inhibited scopolamine-induced memory
impairment, which was measured by Morris water maze test and passive avoidance test. Instant
decaffeinated coffee suppressed scopolamine-mediated elevation of tumor necrosis factor- (TNF- )
and stimulation of nuclear factor- B (NF- B) pathway (i.e., phosphorylation of I B and p65) in the rat
hippocampus.
Discussion: These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment
in human through the inhibition of NF- B activation and subsequent TNF- production.
© 2013 Elsevier B.V. All rights reserved.
Department
Dept. of Pharmacology (약리학)
Publisher
School of Medicine
Citation
Young Jin Jang et al. (2013). Decaffeinated coffee prevents scopolamine-induced memory
impairment in rats. Behavioural Brain Research, 245, 113–119. doi: 10.1016/j.bbr.2013.02.003
Type
Article
ISSN
0166-4328
DOI
10.1016/j.bbr.2013.02.003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35149
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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