Decaffeinated coffee prevents scopolamine-induced memory
impairment in rats
- Young Jin Jang; Jiyoung Kim; Jaesung Shim; Chang-Yul Kim; Jung-Hee Jang; Ki Won Lee; Hyong Joo Lee
- Dept. of Pharmacology (약리학)
- Issue Date
- Behavioural Brain Research, Vol.245() : 113-119, 2013
- Introduction: Several human studies have reported that coffee consumption improves cognitive performance.
In the present study, we investigated whether instant decaffeinated coffee also ameliorates
cognitive performance and attenuates the detrimental effects of scopolamine on memory.
Methods: Memory performance was evaluated in Morris water maze test and passive avoidance test.
Instant decaffeinated coffee (p.o.) at 120 or 240 mg/kg in Sprague-Dawley rats, which is equivalent to
approximately three or six cups of coffee, respectively, in a 60 kg human, was administered for two
Results: Oral gavage administration of instant decaffeinated coffee inhibited scopolamine-induced memory
impairment, which was measured by Morris water maze test and passive avoidance test. Instant
decaffeinated coffee suppressed scopolamine-mediated elevation of tumor necrosis factor- (TNF- )
and stimulation of nuclear factor- B (NF- B) pathway (i.e., phosphorylation of I B and p65) in the rat
Discussion: These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment
in human through the inhibition of NF- B activation and subsequent TNF- production.
© 2013 Elsevier B.V. All rights reserved.
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- 1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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