계명대학교 의학도서관 Repository

Decaffeinated coffee prevents scopolamine-induced memory impairment in rats

Metadata Downloads
Author(s)
장정희
Alternative Author(s)
Jang, Jung Hee
Publication Year
2013
Abstract
Introduction: Several human studies have reported that coffee consumption improves cognitive performance.
In the present study, we investigated whether instant decaffeinated coffee also ameliorates
cognitive performance and attenuates the detrimental effects of scopolamine on memory.
Methods: Memory performance was evaluated in Morris water maze test and passive avoidance test.
Instant decaffeinated coffee (p.o.) at 120 or 240 mg/kg in Sprague-Dawley rats, which is equivalent to
approximately three or six cups of coffee, respectively, in a 60 kg human, was administered for two
weeks.
Results: Oral gavage administration of instant decaffeinated coffee inhibited scopolamine-induced memory
impairment, which was measured by Morris water maze test and passive avoidance test. Instant
decaffeinated coffee suppressed scopolamine-mediated elevation of tumor necrosis factor- (TNF- )
and stimulation of nuclear factor- B (NF- B) pathway (i.e., phosphorylation of I B and p65) in the rat
hippocampus.
Discussion: These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment
in human through the inhibition of NF- B activation and subsequent TNF- production.
© 2013 Elsevier B.V. All rights reserved.
Department
Dept. of Pharmacology (약리학)
Publisher
School of Medicine
Citation
Behavioural Brain Research, Vol.245(null) : 113-119, 2013
Type
Article
ISSN
0166-4328
DOI
10.1016/j.bbr.2013.02.003
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35149
Authorize & License
  • AuthorizeOpen
  • EmbargoForever
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.