Axl is a novel target of withaferin A in the induction of apoptosis
and the suppression of invasion
- Affiliated Author(s)
- 김신; 박종욱; 권택규; 김동은
- Alternative Author(s)
- Kim, Shin; Park, Jong Wook; Kwon, Taeg Kyu; Kim, Dong Eun
- Journal Title
- Biochemical and Biophysical Research Communications
- ISSN
- 0006-291X
- Issued Date
- 2014
- Abstract
- Withaferin A, a withanolide derived from the medicinal plant Withania somnifera, has been reported to exhibit anti-tumorigenic activity against various cancer cells. In this study, we show that withaferin A inhibits the constitutive and recombinant human growth-arrest-specific protein 6 (rhGas6)-induced phosphorylation of Axl and STAT3. In addition, withaferin A also induces the down-regulation of Axl protein expression in a lysosome-dependent manner and inhibits rhGas6-induced wound healing and cell migration. Furthermore, the overexpression of Axl attenuates withaferin A-induced apoptosis. Taken together, the data from the present study indicate that the withaferin A-mediated down-regulation of the Gas6/Axl signaling pathway mediates the inhibition of cell migration and the induction of apoptosis.
Keywords
Withaferin A;
Axl;
Gas6;
Migration;
Apoptosis
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