A small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation

Authors
Ha Young LeeKyoung Sun ParkMi-Kyoung KimTaehoon LeeSung Ho RyuKyung Jin WooTaeg Kyu KwonYoe-Sik Bae
Department
Dept. of Immunology (면역학)
Issue Date
2005
Citation
Biochemical and Biophysical Research Communications, Vol.336(2) : 716-722, 2005
ISSN
0006-291X
Abstract
Matrix metalloproteinase-9 (MMP-9) is critically involved in the tumor invasion and metastasis processes. Since TNF-α plays a crucial role in the regulation of MMP-9 expression, the development of molecules capable of modulating TNF-α-induced signaling is an issue of concern. We identified a novel synthetic compound that inhibits TNF-α-induced MMP-9 upregulation in the HT1080 human fibrosarcoma cell line. The active compound SM-7368 inhibited TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and showed maximal activity at 10 μM. SM-7368 inhibited TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. We also found that SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. Moreover, we found that SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line. Taken together, our results demonstrate that SM-7368 is a synthetic compound that inhibits TNF-α-induced MMP-9 expression, and thus SM-7368 should be useful for the development of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis. Keywords Matrix metalloproteinase-9; TNF-α; Small compound; NF-κB; Invasion
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35176
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Keimyung Author(s)
권택규
Full Text
https://linkinghub.elsevier.com/retrieve/pii/S0006291X05018711
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