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Excitatory GABAA receptor in autonomic pelvic ganglion neurons innervating bladder

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Author(s)
김나현
Alternative Author(s)
Kim, Na Hyun
Publication Year
2014
Abstract
Major pelvic ganglia (MPG) are relay centers for autonomic reflexes such as micturition and penile erection. MPG innervate the urogenital system, including bladder. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system, and may also play an important role in some peripheral autonomic ganglia, including MPG. However, the electrophysiological properties and function of GABAA receptor in MPG neurons innervating bladder remain unknown. This study examined the electrophysiological properties and functional roles of GABAA receptors in bladder-innervating neurons identified by retrograde Dil tracing. Neurons innervating bladder showed previously established parasympathetic properties, including small membrane capacitance, lack of T-type Ca2+ channel expression, and tyrosine-hydroxylase immunoreactivity. GABAA receptors were functionally expressed in bladder innervating neurons, but GABAC receptors were not. GABA elicited strong depolarization followed by increase of intracellular Ca2+ in neurons innervating bladder, supporting the hypothesis GABA may play an important role in bladder function. These results provide useful information about the autonomic function of bladder in physiological and pathological conditions.

Keywords
GABAA receptor;
Autonomic neuron;
Bladder;
Major pelvic ganglion neurons
Department
Dept. of Nursing (간호학)
Publisher
College of Nursing
Citation
Biochemical and Biophysical Research Communications, Vol.447(1) : 205-209, 2014
Type
Article
ISSN
0006-291X
DOI
10.1016/j.bbrc.2014.03.136
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35196
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