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The antifibrotic effect of TGF-β1 siRNAs in murine model of liver cirrhosis

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Author(s)
김현철
Alternative Author(s)
Kim, Hyun Chul
Publication Year
2006
Abstract
Liver fibrosis results from chronic damage to the liver by chronic hepatitis, alcohol, and toxic agents. A characteristic of liver fibrosis is an accumulation of extracellular matrix (ECM) protein, which distorts the hepatic architecture by forming a fibrous scar, and the subsequent development of regenerating nodules defines cirrhosis. Transforming growth factor (TGF)-β1, one of the most powerful profibrogenic mediators, plays a major role in the development of liver cirrhosis and regulates ECM gene expression and matrix degradation. This study elucidates the changes of TGF-β1-mediated signals during liver fibrogenesis by using RNA interference. In this experiment, the TGF-β1 siRNAs reduced the expression of TGF-β1 in the livers of CCl4 injection compared with those of control group, and the expression of type I collagen and α-smooth muscle actin was decreased. In conclusion, this study demonstrates that TGF-β1 siRNAs inhibit TGF-β1 expression in the murine model of liver cirrhosis and might be a good therapeutic strategy to prevent liver cirrhosis in human.

Keywords
TGF-β1;
RNA interference;
siRNA;
Liver cirrhosis
Department
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Publisher
School of Medicine
Citation
Biochemical and Biophysical Research Communications, Vol.343(4) : 1072-1078, 2006
Type
Article
ISSN
0006-291X
DOI
10.1016/j.bbrc.2006.03.087
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35203
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