The antifibrotic effect of TGF-β1 siRNAs in murine model of liver cirrhosis

Kyung-Hyun KimHyun-Chul KimMee-Yul HwangHoon-Kyu OhTae-Sung LeeYoung-Chae ChangHo-Jung SongNam-Hee WonKwan-Kyu Park
Dept. of Internal Medicine (내과학); Kidney Institute (신장연구소)
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Biochemical and Biophysical Research Communications, Vol.343(4) : 1072-1078, 2006
Liver fibrosis results from chronic damage to the liver by chronic hepatitis, alcohol, and toxic agents. A characteristic of liver fibrosis is an accumulation of extracellular matrix (ECM) protein, which distorts the hepatic architecture by forming a fibrous scar, and the subsequent development of regenerating nodules defines cirrhosis. Transforming growth factor (TGF)-β1, one of the most powerful profibrogenic mediators, plays a major role in the development of liver cirrhosis and regulates ECM gene expression and matrix degradation. This study elucidates the changes of TGF-β1-mediated signals during liver fibrogenesis by using RNA interference. In this experiment, the TGF-β1 siRNAs reduced the expression of TGF-β1 in the livers of CCl4 injection compared with those of control group, and the expression of type I collagen and α-smooth muscle actin was decreased. In conclusion, this study demonstrates that TGF-β1 siRNAs inhibit TGF-β1 expression in the murine model of liver cirrhosis and might be a good therapeutic strategy to prevent liver cirrhosis in human. Keywords TGF-β1; RNA interference; siRNA; Liver cirrhosis
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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