계명대학교 의학도서관 Repository

The antifibrotic effect of TGF-β1 siRNAs in murine model of liver cirrhosis

Metadata Downloads
Author(s)
Kyung-Hyun KimHyun-Chul KimMee-Yul HwangHoon-Kyu OhTae-Sung LeeYoung-Chae ChangHo-Jung SongNam-Hee WonKwan-Kyu Park
Keimyung Author(s)
Kim, Hyun Chul
Department
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Journal Title
Biochemical and Biophysical Research Communications
Issued Date
2006
Volume
343
Issue
4
Abstract
Liver fibrosis results from chronic damage to the liver by chronic hepatitis, alcohol, and toxic agents. A characteristic of liver fibrosis is an accumulation of extracellular matrix (ECM) protein, which distorts the hepatic architecture by forming a fibrous scar, and the subsequent development of regenerating nodules defines cirrhosis. Transforming growth factor (TGF)-β1, one of the most powerful profibrogenic mediators, plays a major role in the development of liver cirrhosis and regulates ECM gene expression and matrix degradation. This study elucidates the changes of TGF-β1-mediated signals during liver fibrogenesis by using RNA interference. In this experiment, the TGF-β1 siRNAs reduced the expression of TGF-β1 in the livers of CCl4 injection compared with those of control group, and the expression of type I collagen and α-smooth muscle actin was decreased. In conclusion, this study demonstrates that TGF-β1 siRNAs inhibit TGF-β1 expression in the murine model of liver cirrhosis and might be a good therapeutic strategy to prevent liver cirrhosis in human.

Keywords
TGF-β1;
RNA interference;
siRNA;
Liver cirrhosis
Keimyung Author(s)(Kor)
김현철
Publisher
School of Medicine
Citation
Kyung-Hyun Kim et al. (2006). The antifibrotic effect of TGF-β1 siRNAs in murine model of liver cirrhosis. Biochemical and Biophysical Research Communications, 343(4), 1072–1078. doi: 10.1016/j.bbrc.2006.03.087
Type
Article
ISSN
0006-291X
Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X06006024
DOI
10.1016/j.bbrc.2006.03.087
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35203
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.