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Brain-derived neurotrophic factor rapidly potentiates synaptic transmission through NMDA, but suppresses it through non-NMDA receptors in rat hippocampal neuron

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Author(s)
Dae-Kyu SongByung-kil ChoeJae Hoon BaeWon Kyun ParkIn Sook HanWon-Kyung HoYung E. Earm
Publication Year
1998
Abstract
Brain-derived neurotrophic factor (BDNF) rapidly enhances synaptic transmission among the hippocampal neurons. In order to examine which component of glutamate receptors participates in synaptic potentiation by BDNF, we have studied the effect of glutamate antagonists on excitatory postsynaptic currents (EPSCs) enhanced by BDNF, using cultured embryonic hippocampal neurons. In the presence of AP5, a N-methyl-D-aspartate (NMDA) antagonist, BDNF depressed the EPSCs. In contrast, BDNF enhanced the EPSCs in the presence of a non-NMDA antagonist CNQX. Our results suggest that BDNF acutely activates synaptic transmission via NMDA, but suppresses it via non-NMDA receptors in the hippocampus.
Department
Dept. of Medical Education (의학교육학)
Dept. of Physiology (생리학)
Publisher
School of Medicine
Citation
Brain Research, Vol.799(1) : 176-179, 1998
Type
Article
ISSN
0006-8993
DOI
10.1016/S0006-8993(98)00474-0
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35240
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