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Immune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis

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Affiliated Author(s)
최원일권건영
Alternative Author(s)
Choi, Won IlKwon, Kun Young
Journal Title
BMC Immunology
ISSN
1471-2172
Issued Date
2012
Abstract
Background
Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients without pulmonary tuberculosis.


Methods

Patients with any evidence of pulmonary tuberculosis, either from radiologic or bacteriologic evaluation, were excluded. Bronchoalveolar lavage fluid (BALF) was collected from 10 newly diagnosed, untreated, HIV-negative TPE patients and 10 healthy controls. We analyzed T-lymphocyte subpopulations and measured 10 cytokines in BALF. Cytokine levels in BALF were standardised using urea.


Results

The concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and the CD4+/CD8+ ratio of T-lymphocytes were significantly higher in TPE patients without pulmonary tuberculosis than in the controls. Of the cytokines measured in BALF, VEGF showed the highest concentration. No difference was observed in T-helper type 2 cytokines between the 2 groups.


Conclusion

There were significant immune responses and increases in IFN-γ, TNF-α, and VEGF in the lung parenchyma of TPE patients without pulmonary tuberculosis. This result suggests that TPE may induce a significant immune response in lung parenchyma.

Keywords: Interferon-γ, Tuberculosis, Tumor necrosis factor-α, Vascular endothelial growth factor
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Diana Qama et al. (2012). Immune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis. BMC Immunology, 13(1), 45–45. doi: 10.1186/1471-2172-13-45
Type
Article
ISSN
1471-2172
DOI
10.1186/1471-2172-13-45
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35241
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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