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dc.contributor.authorDiana Qama-
dc.contributor.authorWon-Il Choi-
dc.contributor.authorKun Young Kwon-
dc.date.accessioned2018-08-09T16:34:50Z-
dc.date.available2018-08-09T16:34:50Z-
dc.date.issued2012-
dc.identifier.citationBMC Immunology, Vol.13(1) : 45-45, 2012-
dc.identifier.issn1471-2172-
dc.identifier.otheroak-aaa-00663-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/35241-
dc.description.abstractBackground Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients without pulmonary tuberculosis. Methods Patients with any evidence of pulmonary tuberculosis, either from radiologic or bacteriologic evaluation, were excluded. Bronchoalveolar lavage fluid (BALF) was collected from 10 newly diagnosed, untreated, HIV-negative TPE patients and 10 healthy controls. We analyzed T-lymphocyte subpopulations and measured 10 cytokines in BALF. Cytokine levels in BALF were standardised using urea. Results The concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), and the CD4+/CD8+ ratio of T-lymphocytes were significantly higher in TPE patients without pulmonary tuberculosis than in the controls. Of the cytokines measured in BALF, VEGF showed the highest concentration. No difference was observed in T-helper type 2 cytokines between the 2 groups. Conclusion There were significant immune responses and increases in IFN-γ, TNF-α, and VEGF in the lung parenchyma of TPE patients without pulmonary tuberculosis. This result suggests that TPE may induce a significant immune response in lung parenchyma. Keywords: Interferon-γ, Tuberculosis, Tumor necrosis factor-α, Vascular endothelial growth factor-
dc.description.statementofresponsibilityopen-
dc.publisherSchool of Medicine-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.titleImmune responses in the lungs of patients with tuberculous pleural effusion without pulmonary tuberculosis-
dc.typeArticle-
dc.contributor.localauthor최원일-
dc.contributor.localauthor권건영-
dc.contributor.alternativelocalauthorChoi, Won Il-
dc.contributor.alternativelocalauthorKwon, Kun Young-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.citation.volume13-
dc.citation.number1-
dc.citation.startpage45-
dc.citation.titleBMC Immunology-
dc.citation.endpage45-
dc.identifier.doi10.1186/1471-2172-13-45-


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