Unusual Cytotoxic Phenethylamides from Xenorhabdus nematophilus

Abstract

Three simple carboxamides incorporating the phenethylamine moiety have been isolated from strain XR-NC of a symbiotic bacterium Xenorhabdus nematophilus. Their structures were identified by spectroscopic data and synthesis. The compounds exhibited significant cytotoxicities against human cancer-cell line, viz. the gastric adenocarcinoma, colon adenocarcinoma and lung adenocarcinoma. Keywords : Xenorhabdus nematophilus, Phenethylamides, Xenorhabdins.