A multi-center phase II study of docetaxel plus cisplatin as first-line therapy in patients with metastatic squamous cell esophageal cancer

Authors
Jin Young KimYoung Rok DoKeon Uk ParkMin Kyung KimKyung Hee LeeSung Hwa BaeHun Mo RyooJin Ho BaekHong Suk Song
Department
Dept. of Internal Medicine (내과학)
Issue Date
2010
Citation
Cancer Chemotherapy and Pharmacology, Vol.66(1) : 31-36, 2010
ISSN
0344-5704
Abstract
Objective : The objective of this study was to evaluate the efficacy and toxicity of docetaxel and cisplatin combination chemotherapy in patients with metastatic esophageal cancer. Methods : Patients with untreated metastatic squamous cell esophageal cancer, which was histologically proven with at least one measurable lesion, were eligible for the study. Docetaxel 70 mg/m2 and cisplatin 70 mg/m2 were intravenously given on day 1 of 21 days schedule. Results : From December 2004 to December 2007, total of 39 patients (M/F = 39/0) were enrolled. The median age was 65 years. Thirty-four patients were evaluable for response. There were 3 (7.7%) complete remission, 10 (25.6%) partial remission, 11 (28.2%) stable disease, and 10 (25.6%) progression disease. The objective tumor response rate was 33.3% in intention-to-treat (ITT). Median PFS was 5.0 months and median survival was 8.3 months. Median number of cycles administered was 3. The relative dose intensity of docetaxel and cisplatin was 92 and 91%, respectively. This treatment was comparatively tolerated with grade 3/4 neutropenia in 20.5%/10.3%, grade 3 infection in 2.6% of patients. Conclusion : Docetaxel plus cisplatin combination chemotherapy showed promising antitumor activity with manageable toxicities in patients with metastatic squamous esophageal cancer. Keywords : Esophageal cancer – Docetaxel – Cisplatin – Combination chemotherapy
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35286
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
김진영; 도영록; 박건욱; 송홍석
Full Text
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs00280-009-1130-6
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