A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma

Hyun Young WooSi Hyun BaeJun Yong ParkKwang Hyub HanHo Jong ChunByung Gil ChoiHyeon U. ImJong Young ChoiSeung Kew YoonJae Youn CheongSung Won ChoByoung Kuk JangJae Seok HwangSang Gyune KimYoung Seok KimYeon Seok SeoHyung Joon YimSoon Ho Um
Dept. of Internal Medicine (내과학)
Issue Date
Cancer Chemotherapy and Pharmacology, Vol.65(2) : 373-382, 2010
Purpose : Hepatic arterial infusion chemotherapy (HAIC) has been reported to be effective in patients with advanced hepatocellular carcinoma (HCC). Methods : In this multicenter, prospective, open-labeled, clinical trial, we randomly assigned 68 patients with advanced HCC to receive either low-dose [n = 32, 5-fluorouracil (FU), 170 mg/m2 and cisplatin, 7 mg/m2 on days 1–5] or high-dose HAIC (n = 36, 5-FU, 500 mg/m2 on days 1–3 and cisplatin, 60 mg/m2 on day 2) every 4 weeks via an implantable port system. Results : A total of 207 cycles of HAIC was given to the 68 patients. Overall, 6 patients (8.8%) achieved a partial response and 21 patients (30.9%) had stable disease. The objective response rate (CR + PR) was significantly improved in the high-dose group compared to the low-dose group (16.7% vs. 0%, P = 0.024). The median time to disease progression and overall survival were slightly prolonged in the high-dose group compared to the low-dose group (median survival, 193 vs. 153 days; P = 0.108; median time to disease progression, 145 vs. 90 days; P = 0.095). Multivariate analysis showed that tumor response to treatment [P = 0.007, RR 2.27 (95% CI, 1.248–4.132)] was the only factor associated with overall survival. All adverse events were tolerable and successfully managed in both treatment groups. Conclusions : Both HAIC regimens are safe and effective in patients with advanced HCC. High-dose HAIC achieves a better tumor response compared to low-dose HAIC. Keywords : Hepatocellular carcinoma – Hepatic arterial infusion chemotherapy – High dose – Low dose – 5-Fluorouracil – Cisplatin
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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장병국; 황재석
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