계명대학교 의학도서관 Repository

Gemcitabine and oxaliplatin combination as first-line treatment for advanced pancreatic cancer: a multicenter phase II study

Metadata Downloads
Author(s)
송홍석
Alternative Author(s)
Song, Hong Suk
Publication Year
2009
Abstract
Purpose : Gemcitabine is the only drug approved for single-agent therapy in advanced pancreatic carcinoma (APC). Gemcitabine-based combination chemotherapy has not yet shown promising results.
Methods : This multicenter phase II study enrolled previously untreated patients with locally advanced and/or metastatic pancreatic adenocarcinoma. Patients received 1,000 mg/m2 gemcitabine, 100-min infusion, day 1 and 100 mg/m2 oxaliplatin, 2-h infusion, day 2; q2w. The primary end point was response rate (RR).
Results : Thirteen study centers enrolled 48 eligible patients of which 44 were evaluable. The RR, median overall survival, and median time to progression were 18.2%, 9.4 and 5.6 months, respectively. Sixteen patients (36.4%) experienced clinical benefit. The global quality of life scores improved by 11.71. Grade 3/4 peripheral sensory neuropathy was noted (2.1%), while the most common hematologic toxicity was anemia (grade 3/4, 6.3%).
Conclusions : Gemcitabine and oxaliplatin combination chemotherapy showed a promising activity in APC patients and was well tolerated.
Keywords : Advanced pancreatic cancer – Combination chemotherapy – Gemcitabine – GEMOX – Oxaliplatin
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Cancer Chemotherapy and Pharmacology, Vol.64(2) : 317-325, 2009
Type
Article
ISSN
0344-5704
DOI
10.1007/s00280-008-0873-9
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35288
Authorize & License
  • AuthorizeOpen
  • EmbargoForever
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.