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Cytogenetic and Fluorescence In Situ Hybridization Analyses of Hematologic Malignancies in Korea

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Author(s)
Sun Hoe KooGye Chul KwonHyo Jin ChunJong Woo Park
Publication Year
1998
Abstract
Cytogenetic analysis was performed in 86 cases of hematologic malignancy, using conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) analysis at two university hospitals in Korea between 1993 and 1995. In addition to well-known anomalies, some unusual abnormalities were found, such as t(17;22), trisomy 9 combined with t(14;17), (2;7) and Philadelphia chromosome in CML; t(1;12), t(11;22), t(9;17), and t(12;21) in AML; trisomy 11 in MDS; t(2;9) and complex t(8;8;13;14) in ALL. The results of FISH analysis in interphase nuclei using a translocation probe for CML and APL showed more than 85% positive cells in CML, and 75% positive cells in APL.
Department
Dept. of Laboratory Medicine (진단검사의학)
Publisher
School of Medicine
Citation
Cancer Genetics and Cytogenetics, Vol.101(1) : 1-6, 1998
Type
Article
ISSN
0165-4608
DOI
10.1016/S0165-4608(97)00357-9
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35310
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