Cytogenetic and Fluorescence In Situ Hybridization Analyses of Hematologic Malignancies in Korea

Authors
Sun Hoe KooGye Chul KwonHyo Jin ChunJong Woo Park
Department
Dept. of Laboratory Medicine (진단검사의학)
Issue Date
1998
Citation
Cancer Genetics and Cytogenetics, Vol.101(1) : 1-6, 1998
ISSN
0165-4608
Abstract
Cytogenetic analysis was performed in 86 cases of hematologic malignancy, using conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) analysis at two university hospitals in Korea between 1993 and 1995. In addition to well-known anomalies, some unusual abnormalities were found, such as t(17;22), trisomy 9 combined with t(14;17), (2;7) and Philadelphia chromosome in CML; t(1;12), t(11;22), t(9;17), and t(12;21) in AML; trisomy 11 in MDS; t(2;9) and complex t(8;8;13;14) in ALL. The results of FISH analysis in interphase nuclei using a translocation probe for CML and APL showed more than 85% positive cells in CML, and 75% positive cells in APL.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35310
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
Keimyung Author(s)
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Full Text
https://www.sciencedirect.com/science/article/pii/S0165460897003579?via%3Dihub
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