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Pentamidine reduces expression of hypoxia-inducible factor-1a in DU145 and MDA-MB-231 cancer cells

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Author(s)
백원기서성일서민호박종욱
Alternative Author(s)
Baek, Won KiSuh, Seong IlSuh, Min HoPark, Jong Wook
Publication Year
2011
Abstract
Pentamidine is an aromatic diamine used for the treatment of human protozoa infections. Recently, pentamidine has been reported to exhibit anticancer properties. In this study, we report that pentamidine inhibits expression of hypoxia-inducible factor (HIF)-1α in cancer cells. Pentamidine decreased HIF-1α protein translation and enhanced its protein degradation in DU145 prostate cancer and MDA-MB-231 breast cancer cells. In parallel with reduction of de novo synthesis of HIF-1α, pentamidine was able to suppress global protein translation, an effect accompanied by the reduction of eIF4F complex formation and also the induction of eIF2α phosphorylation. These results show that pentamidine is a potential inhibitor of HIF-1α and its potential as a cancer therapeutic reagent warrants further study.

Keywords
Hypoxia-inducible factor-1α;
Pentamidine;
Protein translation
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Cancer Letters, Vol.303(1) : 39-46, 2011
Type
Article
ISSN
0304-3835
DOI
10.1016/j.canlet.2011.01.008
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35314
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