Lysophosphatidic acid induces glycodelin gene expression in cancer cells

Authors
Sumathi RamachandranSreemathy RamaswamyChi-Heum ChoSampath Parthasarathy
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Issue Date
2002
Citation
Cancer Letters, Vol.177(2) : 197-202, 2002
ISSN
0304-3835
Abstract
Glycodelin is a glycoprotein that has been suggested to be important in normal pregnancy and in malignancy. The regulation of its synthesis has not been studied. In this study, we report the induction of glycodelin gene expression by lysophosphatidic acid (LPA). We studied the effect of LPA (5, 10 and 25 μM) on glycodelin production in breast (MDA-MB-231), cervical (Hela), endometrial (RL-95), ovarian cancer (OVCAR-3) and erythroleukemia (K562) cells. There was a dose-dependent (5–25 μM) induction of glycodelin gene and protein expression in these cell types. LPA is a mimic of phorbol myristate acetate (PMA) action and is found to be elevated in high concentrations in the serum of cancer subjects. As glycodelin is an angiogenic protein with a potential immunosuppressive role, control of LPA synthesis might offer a potential target for intervention. Keywords Glycodelin; Lysophosphatidic acid; Tumor; Immunosuppression
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35322
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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Full Text
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304383501008072?via%3Dihub
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