Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

Authors
Mi Jin YoonEun Hee KimTaeg Kyu KwonSun Ah ParkKyeong Sook Choi
Department
Dept. of Immunology (면역학)
Issue Date
2012
Citation
Cancer Letters, Vol.324(2) : 197-209, 2012
ISSN
0304-3835
Abstract
In this study, we investigated the role of Ca2+ in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca2+ overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na+/Ca2+ exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca2+ overload and effectively induce paraptosis in malignant breast cancer cells. Keywords Paraptosis; Curcumin; Mitochondrial Ca2+; Proteasomal inhibition; Breast cancer
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35325
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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Full Text
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0304383512003126?via%3Dihub
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