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Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells

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Author(s)
권택규
Alternative Author(s)
Kwon, Taeg Kyu
Publication Year
2012
Abstract
In this study, we investigated the role of Ca2+ in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca2+ overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na+/Ca2+ exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca2+ overload and effectively induce paraptosis in malignant breast cancer cells.

Keywords
Paraptosis;
Curcumin;
Mitochondrial Ca2+;
Proteasomal inhibition;
Breast cancer
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Cancer Letters, Vol.324(2) : 197-209, 2012
Type
Article
ISSN
0304-3835
DOI
10.1016/j.canlet.2012.05.018
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35325
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