Dykellic Acid Inhibits Phorbol Myristate Acetate-induced Matrix Metalloproteinase-9 Expression by Inhibiting Nuclear Factor κB Transcriptional Activity

Authors
Ju-Hyung WooJong-Wook ParkSung-Hee LeeYoung-Ho KimIn Kyu LeeEdward GabrielsonSang-Han LeeHo-Jae LeeYung-Hee KhoTaeg Kyu Kwon
Department
Dept. of Immunology (면역학); Dept. of Internal Medicine (내과학)
Issue Date
2003
Citation
Cancer Research, Vol.63(12) : 3430-3434, 2003
ISSN
0008-5472
Abstract
Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. These effects of dykellic acid are time- and dose-dependent, and correlate with decreased MMP-9 promoter activity and mRNA expression. Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35337
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
박종욱; 권택규; 이인규
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