IB-MECA and Cardioprotection

Authors
Zhelong XuYeongho JangRobert A. MuellerEdward A. Norfleet
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Issue Date
2006
Citation
Cardiovascular Drug Reviews, Vol.24(3-4) : 227-238, 2006
ISSN
0897-5957
Abstract
Keywords: Adenosine A3 receptor; Cardioprotection; IB-MECA; Ischemia/reperfusion injury The adenosine A3 receptor plays an important role in ischemic preconditioning. Activation of the adenosine A3 receptor with its agonists induces both early and late pharmacological preconditioning through various mechanisms. As the first potent and selective adenosine A3 receptor agonist, IB-MECA (N6-(3-iodobenzyl)-adenosine-5′-N-methylcarboxamide) has been demonstrated to induce cardioprotection against myocardial ischemia/reperfusion injury when given before onset of ischemia by triggering pharmacological preconditioning. More importantly, IB-MECA can also protect the heart even when administered at the onset of reperfusion after ischemia, indicating a strong likelihood that the drug may be useful for the treatment of patients with acute myocardial infarction. However, since IB-MECA has been reported to have lethal effects at higher concentrations, and may cause systemic hypertension in some species, further studies are needed to find the best treatment strategy to increase its therapeutic potential.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35367
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Keimyung Author(s)
장영호
Full Text
http://dx.doi.org.proxy.dsmc.or.kr/10.1111/j.1527-3466.2006.00227.x
File in this Item
 사서에게 요청하기
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE