계명대학교 의학도서관 Repository

IB-MECA and Cardioprotection

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Affiliated Author(s)
장영호
Alternative Author(s)
Jang, Young Ho
Journal Title
Cardiovascular Drug Reviews
ISSN
0897-5957
Issued Date
2006
Abstract
Keywords:

Adenosine A3 receptor;
Cardioprotection;
IB-MECA;
Ischemia/reperfusion injury





The adenosine A3 receptor plays an important role in ischemic preconditioning. Activation of the adenosine A3 receptor with its agonists induces both early and late pharmacological preconditioning through various mechanisms. As the first potent and selective adenosine A3 receptor agonist, IB-MECA (N6-(3-iodobenzyl)-adenosine-5′-N-methylcarboxamide) has been demonstrated to induce cardioprotection against myocardial ischemia/reperfusion injury when given before onset of ischemia by triggering pharmacological preconditioning. More importantly, IB-MECA can also protect the heart even when administered at the onset of reperfusion after ischemia, indicating a strong likelihood that the drug may be useful for the treatment of patients with acute myocardial infarction. However, since IB-MECA has been reported to have lethal effects at higher concentrations, and may cause systemic hypertension in some species, further studies are needed to find the best treatment strategy to increase its therapeutic potential.
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Publisher
School of Medicine
Citation
Zhelong Xu et al. (2006). IB-MECA and Cardioprotection. Cardiovascular Drug Reviews, 24(3–4), 227–238. doi: 10.1111/j.1527-3466.2006.00227.x
Type
Article
ISSN
0897-5957
DOI
10.1111/j.1527-3466.2006.00227.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35367
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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