Comparison of Three-Year Clinical Outcomes Between Sirolimus-Versus Paclitaxel-Eluting Stents in Diabetic Patients: Prospective Randomized Multicenter Trial

Authors
Soon Jun HongMoo Hyun KimKwang Soo ChaHun Sik ParkShung Chull ChaeSeung Ho HurHyeon Cheol GwonJang Ho BaeDo-Sun Lim
Department
Dept. of Internal Medicine (내과학)
Issue Date
2010
Citation
Catheterization and Cardiovascular Interventions, Vol.76(7) : 924-933, 2010
ISSN
1522-1946
Abstract
Keywords: drug-eluting stents; diabetes mellitus; survival analysis; major adverse cardiac event; stent thrombosis Background: Three-year follow-up of major adverse cardiovascular event (MACE) (death, nonfatal myocardial infarction, target lesion revascularization) and the predictors of MACEs in diabetic patients after sirolimus-eluting stent (SES) or paclitaxel-eluting stent (PES) implantation have not been reported. Methods: Diabetic patients with de novo coronary lesions (169 patients with 190 lesions) were randomly assigned prospectively to either SES or PES. Results: Baseline characteristics were similar between the two groups. The rates of MACEs [5.9% (n = 5) in the SES vs. 9.5% (n = 8) in the PES Group, P = 0.374] and definite stent thrombosis [1.2% (n = 1) in the SES vs. 3.6% (n = 3) in the PES Group, P = 0.368] were similar in the two groups during the three-year follow-up. Multivariate logistic analysis showed that insulin treatment was the only independent predictor of MACE [odds ratio (OR) 8.60, 95% confidence interval (CI) 3.25–22.76, P < 0.001] and target vessel revascularization (TVR) (OR 9.50, 95% CI 3.07–29.44, P < 0.001) during the three-year follow-up. Conclusions: The rates of MACEs, TVR, and stent thrombosis during the three-year follow-up were similar in the SES and PES Groups. Insulin treatment was a main predictor of MACEs and TVR during the three-year follow-up after either SES or PES implantation.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35375
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/ccd.22369
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