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Expression of neuronal antigens and related ventral and dorsal proteins in the normal spinal cord and a surgically induced open neural tube defect of the spine in chick embryos: an immunohistochemical study

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Author(s)
김동원
Alternative Author(s)
Kim, Dong Won
Publication Year
2010
Abstract
Objective

The aims of this study were to elucidate the processes of neuronal differentiation and ventrodorsal patterning in the spinal cord of the chick embryo from embryonic day (E) 3 to E17 and to study the effect of a prenatal spinal open neural tube defect (ONTD) on these processes.


Method

Expression patterns of neuronal antigens (neuronal nuclear antigen, neurofilament-associated protein (NAP), and synaptophysin) and related ventral markers [sonic hedgehog, paired box gene (PAX)6, and islet-1], and dorsal markers (bone morphogenetic protein, Notch homolog 1, and PAX7) were investigated in the normal spinal cord and in a surgically induced spinal ONTD in chick embryos. Four normal and ONTD chick embryos were used for each antigen group.


Result & Conclusion

There were no differences in the expression of neuronal and ventrodorsal markers between the control and ONTD groups. NAP and synaptophysin were useful for identifying dorsal structures in the distorted anatomy of the ONTD chicks.


Keywords
Spinal cord – Chick embryo – Open neural tube defect – Neuron – Ventral and dorsal markers
Department
Dept. of Neurosurgery (신경외과학)
Publisher
School of Medicine
Citation
Child's Nervous System, Vol.26(5) : 627-636, 2010
Type
Article
ISSN
0256-7040
DOI
10.1007/s00381-009-1049-6
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35406
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