Randomized Comparison of Cilostazol vs Clopidogrel After Drug-Eluting Stenting in Diabetic Patients - CIilostazol for Diabetic Patients in Drug-Eluting Stent (CIDES) Trial -

Youngkeun AhnMyung Ho JeongJong Weon JeongKye Hun KimTae Hoon AhnWoong Chul KangChang-Gyu ParkJong Hyun KimIn-Ho ChaeChang Wook NamSeung-Ho HurJang-Ho BaeKi Young KimSeok Kyu Oh
Dept. of Internal Medicine (내과학)
Issue Date
Circulation Journal, Vol.72(1) : 35-39, 2008
Background Previous studies have shown that cilostazol may not only prevent stent thrombosis, but may also have positive effect in the prevention of restenosis. However, the effect of cilostazol on restenosis after successful deployment of drug-eluting stent (DES) in patients with diabetes mellitus has not been evaluated. Methods and Results A total of 280 patients at 8 clinical sites were randomized. The patients (61.7±9.9 years old, 163 males) who underwent successful stenting were randomized to aspirin and cilostazol (group I, n=141, 61.2±9.6 years old) vs aspirin and clopidogrel (group II, n=139, 62.0±10.0 years old) after 1 month of aspirin, cilostazol, and clopidogrel combination treatment. There were no significant differences in baseline characteristics of the groups. The type of DES implanted did not differ between the groups. There were no differences in angiographic and procedural characteristics of the groups. Major adverse cardiac events, including acute and subacute stent thrombosis within 1 month, did not occur in either group. Cases of angiographic late stent thrombosis were 1 (0.9%) in group I and 1 (0.8%) in group II. Follow-up coronary angiography was performed in 237 patients (84.6%). Mean follow-up duration was 7.1 months. The rate of angiographic restenosis (stent plus 5-mm borders) was 9 (8.0%) in group I and 20 (16.1%) in group II, p=0.041). The minimal luminal diameter at follow-up period in group I was 2.55±0.63 mm compared with 2.41±0.83 mm in group II (p=NS). Conclusions Combination therapy with aspirin and cilostazol for the prevention of stent restenosis is comparable or superior to that of aspirin and clopidogrel in diabetic patients who undergo DES implantation. (Circ J 2008; 72: 35 - 39)
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
남창욱; 허승호
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