계명대학교 의학도서관 Repository

Decreased expression of collagen and fibronectin genes in striae distensae tissue

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Author(s)
이규석송준영장성익서민호
Alternative Author(s)
Lee, Kyu SukSong, Joon YoungChang, Sung IkSuh, Min Ho
Issued Date
1994
Abstract
Summary


Striae distensae are characterized by a thinning of connective tissue stroma to produce linear, atrophic-appearing skin. Excessive adrenocortical activity, genetic factors and inherited defects of connective tissues, etc. are important causative factors in the formation of striae distensae, but the basic aetiology is not known. Total RNA was extracted from skin biopsies of five patients with striae distensae. The expression of genes coding for types I and III procollagen, elastin, fibronectin and β-actin were studied and compared with those of four sex- and age-matched healthy individuals. The percentages of types I and III procollagen mRNA were 9.9 ± 2.9% (mean ± s.d.) and 10.6 ± 1.6%, respectively, of the corresponding controls. The value for fibronectin mRNA in striae distensae was 7.3 ± 1.8% of the control. The steady-state ratio fibronectin/type I procollagen mRNAs was 0.12 ± 0.01 in striae distensae and (MS ± 0.01 in the control.


These observations suggest that expression of collagens, elastin and fibronectin genes are apparently decreased, and that there is a marked alteration of fibroblast metabolism, in striae distensae
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