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Decreased expression of collagen and fibronectin genes in striae distensae tissue

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Affiliated Author(s)
이규석송준영장성익서민호
Alternative Author(s)
Lee, Kyu SukSong, Joon YoungChang, Sung IkSuh, Min Ho
Journal Title
Clinical and Experimental Dermatology
ISSN
0307-6938
Issued Date
1994
Abstract
Summary


Striae distensae are characterized by a thinning of connective tissue stroma to produce linear, atrophic-appearing skin. Excessive adrenocortical activity, genetic factors and inherited defects of connective tissues, etc. are important causative factors in the formation of striae distensae, but the basic aetiology is not known. Total RNA was extracted from skin biopsies of five patients with striae distensae. The expression of genes coding for types I and III procollagen, elastin, fibronectin and β-actin were studied and compared with those of four sex- and age-matched healthy individuals. The percentages of types I and III procollagen mRNA were 9.9 ± 2.9% (mean ± s.d.) and 10.6 ± 1.6%, respectively, of the corresponding controls. The value for fibronectin mRNA in striae distensae was 7.3 ± 1.8% of the control. The steady-state ratio fibronectin/type I procollagen mRNAs was 0.12 ± 0.01 in striae distensae and (MS ± 0.01 in the control.


These observations suggest that expression of collagens, elastin and fibronectin genes are apparently decreased, and that there is a marked alteration of fibroblast metabolism, in striae distensae
Department
Dept. of Dermatology (피부과학)
Dept. of Anatomy (해부학)
Dept. of Microbiology (미생물학)
Publisher
School of Medicine
Citation
K.S. LEE et al. (1994). Decreased expression of collagen and fibronectin genes in striae distensae tissue. Clinical and Experimental Dermatology, 19(4), 285–288. doi: 10.1111/j.1365-2230.1994.tb01196.x
Type
Article
ISSN
0307-6938
DOI
10.1111/j.1365-2230.1994.tb01196.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35467
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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