Reference values for serum levels of insulin-like growth factor-I and insulin-like
growth factor binding protein-3 in Korean children and adolescents
- Sei Eun Hyun; Byung Churl Lee; Byung Kyu Suh; So Chung Chung; Cheol Woo Ko; Heung Sik Kim; Kee Hyoung Lee; Sei Won Yang; Choong Ho Shin; Jin Soon Hwang; Duk Hee Kim; Baek Keun Lim; Jong Duck Kim; Han-Wook Yoo; Hye Soon Kim; Woo Yeong Chung; Mi Jung Park; Young Jong Woo; Chan Jong Kim; Dae-Yeol Lee; Eun Young Kim; Jin Ho Choi; Heon Seok Han; Il Tae Hwang; Ho-Seong Kim
- Dept. of Pediatrics (소아청소년학)
- Issue Date
- Cllinical Biochemistry, Vol.45(1-2) : 16-21, 2012
Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents.
For the study, 1378 healthy Korean children and adolescents aged 0 to 17 years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage
Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13 years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15 years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline.
Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders.
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- 1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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