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Clinical and Angiographic Outcomes of Drug-Eluting Stents in Patients With Large Vessel and Single Coronary Artery Lesion

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Author(s)
조윤경김형섭남창욱허승호김권배
Alternative Author(s)
Cho, Yun KyeongKim, Hyung SeopNam, Chang WookHur, Seung HoKim, Kwon Bae
Publication Year
2010
Abstract
Background


The aim of this study was to evaluate and compare the clinical and angiographic outcomes of 3 drug-eluting stents (DES) in patients with large vessel diameter and single coronary artery lesions.


Hypothesis


The efficacy of 3 DESs may be similar.


Methods


A total of 411 consecutive patients who visited 3 university hospitals from June 2004 to December 2007 and had a single coronary lesion which was treated with the use of a DES that was 3.5 mm in diameter were enrolled in this study. Patients were divided into 3 stent groups: Paclitaxel-eluting stent (PES, n = 105), Sirolimus-eluting stent (SES, n = 259), and Zotarolimus-eluting stent (ZES, n = 47). The study end point was a composite of major adverse cardiac events (MACE) including cardiac death, myocardial infarction (MI), and ischemia-driven target-vessel revascularization (TVR) for 12 months.


Results


Baseline characteristics were not different. Late loss was higher in the ZES group than the other stents (0.5 ± 0.4 mm in SES vs 0.3 ± 0.5 mm in PES, 0.7 ± 0.5 mm in ZES, P = 0.001). The total MACE-free survival rate was not significantly different between the SES group and the PES group (98.8% in SES vs 97.1% in PES, P = 0.252) or the PES group and the ZES group (97.1% in PES vs 93.6% in ZES, P = 0.301). However, the SES group showed a significantly better MACE-free survival rate compared with the ZES group (98.8% in SES vs 93.6% in ZES, P = 0.018).


Conclusions


Clinical and angiographic outcomes of DES in a large vessel diameter and single coronary artery is excellent and SES appears to show better angiographic and clinical outcomes than ZES. Copyright © 2010 Wiley Periodicals, Inc.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Clinical Cardiology, Vol.33(6) : 340-344, 2010
Type
Article
ISSN
0160-9289
DOI
10.1002/clc.20744
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35482
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