Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study

Authors
Yongmin ChangHyuk Won ChangHuijin SongJeonghun KuChristopher J. EarleyRichard P. AllenYong Won Cho
Department
Dept. of Radiology (영상의학); Dept. of Biomedical Engineering (의용공학과); Dept. of Neurology (신경과학)
Issue Date
2015
Citation
Clinical Imaging, Vol.39(1) : 20-25, 2015
ISSN
0899-7071
Abstract
The purpose of this study was to demonstrate whether or not restless legs syndrome (RLS) is associated with any morphological change in gray matter. Forty-six RLS subjects and 46 controls were enrolled. We performed voxel-based morphometry analysis and compared the results of the two groups. The RLS subjects showed significant regional decreases of gray matter volume in the left hippocampal gyrus, both parietal lobes, medial frontal areas and cerebellum (uncorrected, P< .001). We found that RLS patients showed structural alteration in the brain and alterations in certain parts of the brain in RLS patients are relevant to RLS. Keywords Restless legs syndrome; MRI; Voxel-based morphometry; Gray matter
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35492
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
Keimyung Author(s)
장혁원; 구정훈; 조용원
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