계명대학교 의학도서관 Repository

Candida haemulonii and Closely Related Species at 5 University Hospitals in Korea: Identification, Antifungal Susceptibility, and Clinical Features

Metadata Downloads
Author(s)
Mi-Na KimJong Hee ShinHeungsup SungKyungwon LeeEui-Chong KimNamhee RyooJin-Sol LeeSook-In JungKyung Hwa ParkSeung Jung KeeSoo Hyun KimMyung Geun ShinSoon Pal SuhDong Wook 꾜뭏
Publication Year
2009
Abstract
Background. Candida haemulonii, a yeast species that often exhibits antifungal resistance, rarely causes human
infection. During 2004–2006, unusual yeast isolates with phenotypic similarity to C. haemulonii were recovered
from 23 patients (8 patients with fungemia and 15 patients with chronic otitis media) in 5 hospitals in Korea.
Methods. Isolates were characterized using D1/D2 domain and ITS gene sequencing, and the susceptibility of
the isolates to 6 antifungal agents was tested in vitro.
Results. Gene sequencing of the blood isolates confirmed C. haemulonii group I (in 1 patient) and Candida
pseudohaemulonii (in 7 patients), whereas all isolates recovered from the ear were a novel species of which C.
haemulonii is its closest relative. The minimum inhibitory concentration (MIC) ranges of amphotericin B, fluconazole,
itraconazole, and voriconazole for all isolates were 0.5–32 mg/mL (MIC50, 1 mg/mL), 2–128 mg/mL (MIC50,
4 mg/mL), 0.125–4 mg/mL (MIC50, 0.25 mg/mL), and 0.03–2 mg/mL (MIC50, 0.06 mg/mL), respectively. All isolates
were susceptible to caspofungin (MIC, 0.125–0.25 mg/mL) and micafungin (MIC, 0.03–0.06 mg/mL). All cases of
fungemia occurred in patients with severe underlying diseases who had central venous catheters. Three patients
developed breakthrough fungemia while receiving antifungal therapy, and amphotericin B therapeutic failure,
which was associated with a high MIC of amphotericin B (32 mg/mL), was observed in 2 patients.
Conclusions. Candida species that are closely related to C. haemulonii are emerging sources of infection in
Korea. These species show variable patterns of susceptibility to amphotericin B and azole antifungal agents.
Department
Dept. of Laboratory Medicine (진단검사의학)
Publisher
School of Medicine
Citation
Clinical Infectious Diseases, Vol.48(6) : e57-e61, 2009
Type
Article
ISSN
1058-4838
DOI
10.1086/597108
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35493
Authorize & License
  • AuthorizeOpen
  • EmbargoForever
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.