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Potentials of Cystatin C and Uric Acid for Predicting Prognosis of Heart Failure

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Author(s)
김형섭윤혁준박형섭조윤경남창욱허승호김윤년김권배
Alternative Author(s)
Kim, Hyung SeopYoon, Hyuck JunPark, Hyoung SeobCho, Yun KyeongNam, Chang WookHur, Seung HoKim, Yoon NyunKim, Kwon Bae
Publication Year
2013
Abstract
Few studies have explored the clinical potentials of combined
Cystatin C (Cys) and uric acid (UA) in heart failure
(HF). The authors evaluated Cys and UA as predictors of
clinical outcomes compared with conventional renal biomarkers.
This prospective cohort study included 587 HF
patients presenting with dyspnea. At admission, Cys, UA,
and other renal measures including serum urea nitrogen
(BUN), creatinine (Cr), and glomerular filtration rate (GFR)
were obtained. The primary endpoint was the composite of
cardiac death and rehospitalization for worsening HF.
During a 25-month median follow-up period, 68 patients
experienced clinical outcomes: 9 cardiac deaths and 59
HFs. They showed higher BUN and Cr values and lower
GFR. Within these parameters, Cys and UA had the most
favorable area under the curves, and patients with Cys
0.8 mg⁄ L and UA 6.6 mg⁄ dL showed more frequent
events. The net reclassification improvement analysis
showed the combination of Cys and UA had a greater
incremental effect for cardiac prognosis. On multivariate
Cox hazard analysis, Cys and UA were independent
predictive markers for clinical outcomes. In HF patients
presenting with dyspnea, Cys and UA appear to be more
useful predictors of clinical events than other renal
measures
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Congest Heart Failure, Vol.19(3) : 123-129, 2013
Type
Article
ISSN
1527-5299
DOI
10.1111/chf.12012
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35533
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