계명대학교 의학도서관 Repository

Assignment of BUB3 to human chromosome band 10q26 by in situ hybridization

Metadata Downloads
Author(s)
권택규
Alternative Author(s)
Kwon, Taeg Kyu
Publication Year
2000
Abstract
Rationale and significance
Eukaryotic organisms have developed mitotic checkpoints
to inhibit cell division when the mitotic spindle function is
damaged and to assure accurate segregation of replicated chromosomes.
Altered mitotic checkpoints in neoplasia may contribute
to the genomic instability that is characteristic of cancerous
cells (Elledge, 1998; Hardwick, 1998; Lengauer et al.,
1998). Among these checkpoint proteins is Bub3, which is a
kinase substrate for Bub1 and is necessary for Bub1 to bind to
kinetochores before chromosome alignment (Taylor et al.,
1998).
Recently, the cDNA sequence corresponding to the human
homologue of the S. cerevisiae Bub3 mitotic checkpoint protein
has been described and about 34% of the amino acid sequences
are shared between S. cerevisiae and human proteins (Taylor et
al., 1998). In the present study, we determined the chromosome
location of the human BUB3 gene to be 10q26, a locus that is
frequently affected by chromosome loss in human neoplasia
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Cytogenetics and Cell Genetics, Vol.88(42433) : 202-203, 2000
Type
Article
ISSN
0301-0171
DOI
10.1159/000015547
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35545
Authorize & License
  • AuthorizeOpen
  • EmbargoForever
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.