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Response to Rivastigmine Transdermal Patch or Memantine plus Rivastigmine Patch is affected by Apolipoprotein E Genotype in Alzheimer Patients

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Affiliated Author(s)
이현아
Alternative Author(s)
Yi, Hyon Ah
Journal Title
Dementia and Geriatric Cognitive Disorders
ISSN
1420-8008
Issued Date
2012
Abstract
Background/Aims: The apolipoprotein E (APOE) genotype in response to pharmacological treatments in patients with Alzheimer’s disease (AD) remains a matter of controversy. This analysis investigated the effect of the APOE genotype on the clinical response to rivastigmine transdermal patch monotherapy or memantine plus rivastigmine patch in patients with mild to moderate AD. Methods: Two hundred and six (n = 206) patients with probable AD and Mini-Mental State Examination (MMSE) scores of 10–20 were randomized to rivastigmine patch monotherapy or memantine plus rivastigmine patch for 24 weeks. Of the 206 patients with probable AD, 146 patients who consented to genetic testing for APOE were included and assessed for this subgroup study. Results: There were no significant differences on MMSE, NPI, ADAS-cog, ADCS-ADL, CDR-SB, NPI and FAB between rivastigmine patch monotherapy and memantine plus rivastigmine patch according to the APOE genotype. However, patients with moderately severe AD (MMSE ≤15) who were APOE ε4 carriers showed higher responder rates on ADCS-ADL with memantine plus rivastigmine patch compared to rivastigmine patch monotherapy. Conclusion: Moderately severe AD patients with the APOE ε4 allele may respond more favorably to memantine plus rivastigmine patch than ε4 noncarriers.
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine
Citation
Hyun Jeong Han et al. (2012). Response to Rivastigmine Transdermal
Patch or Memantine plus Rivastigmine
Patch is affected by Apolipoprotein E
Genotype in Alzheimer Patients. Dementia and Geriatric Cognitive Disorders, 34(3–4), 167–173. doi: 10.1159/000342927
Type
Article
ISSN
1420-8008
DOI
10.1159/000342927
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35548
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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