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Clinical Improvement of Striae Distensae in Korean Patients Using a Combination of Fractionated Microneedle Radiofrequency and Fractional Carbon Dioxide Laser

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Affiliated Author(s)
김성애류영욱이규석조재위정혜라
Alternative Author(s)
Kim, Sung AeRyoo, Young WookLee, Kyu SukCho, Jae WeJung, Hye Ra
Journal Title
Dermatologic Surgery
ISSN
1076-0512
Issued Date
2013
Abstract
BACKGROUND Striae distensae are dermal scars with flattening and atrophy of the epidermis.
OBJECTIVE To evaluate the efficacy and safety of combination therapy with fractionated microneedle
radiofrequency (RF) and fractional carbon dioxide (CO
2
) laser in the treatment of striae distensae.
MATERIALS AND METHODS Thirty patients (30 female; mean age 33, range 21–51, Fitzpatrick skin type IV)
with moderate to severe striae distensae were enrolled in this study. Patients were divided into three groups:
fractional CO
2
laser only (n = 10), microneedle RF only (n = 10), and combination (n = 10).
RESULTS Improvement was evaluated using a visual analogue scale (range 1–4). Mean clinical improvement
score of the dermatologist was 2.2 in the fractional CO
2
laser–treated group, 1.8 in the microneedle RF–treated
group, and 3.4 in the combination group. Through skin biopsy, we observed thickened epidermis and a clear
increase in the number of collagen fibers in the microneedle RF– and fractional CO
2
combination–treated sites.
Consistent with these results, greater expression of transforming growth factor-b1 and stratifin was observed
in treated sites.
CONCLUSION Combination therapy of fractionated microneedle RF and fractional CO
2
laser is a safe
treatment protocol with a positive therapeutic effect on striae distensae.
The authors have indicated no significant interest with commercial supporters.
Department
Dept. of Dermatology (피부과학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
HAN-WON RYU et al. (2013). Clinical Improvement of Striae Distensae in Korean Patients
Using a Combination of Fractionated Microneedle
Radiofrequency and Fractional Carbon Dioxide Laser. Dermatologic Surgery, 39(10), 1452–1458. doi: 10.1111/dsu.12268
Type
Article
ISSN
1076-0512
DOI
10.1111/dsu.12268
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35553
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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