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Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease

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Affiliated Author(s)
김미경김혜순허승호윤혁준김윤년박근규
Alternative Author(s)
Kim, Mi KyungKim, Hye SoonHur, Seung HoYoon, Hyuck JunKim, Yoon NyunPark, Keun Gyu
Journal Title
Diabetes & Metabolism Journal
ISSN
2233-6079
Issued Date
2011
Abstract
Background: Chemerin is a novel adipokine that is associated with inflammation and adipogenesis. However, it remains unclear
whether chemerin is involved in patients with cardiovascular disease. We investigated whether the serum chemerin levels
of Korean patients with coronary artery disease correlated with specific cardiometabolic parameters.
Methods: In total, 131 patients, all of whom had coronary artery stenosis exceeding 50%, participated in this study. Their serum
chemerin levels and cardiometabolic parameters were measured. The serum chemerin levels of two groups of patients were compared;
those with one stenotic vessel (n=68) and those with multiple stenotic vessels, including left main coronary artery disease
(n=63).
Results: Serum chemerin levels correlated positively with the degree of coronary artery stenosis and fasting glucose, triglyceride,
total cholesterol, low density lipoprotein cholesterol, and high sensitive C-reactive protein levels. The group with multiple
stenotic vessels, including left main disease, had higher chemerin levels than the group with one stenotic vessel (t=-2.129,
P=0.035). Multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease
(odds ratio, 1.018; confidence interval, 0.997 to 1.040; P=0.091).
Conclusion: Serum chemerin levels have a significant correlation with several cardiometabolic risk factors and the degree of
coronary artery stenosis in Korean patients with coronary artery disease. However, multiple binary logistic regression showed
chemerin was not an independent risk factor of multiple vessel disease. Additional investigations are necessary to fully elucidate
the role of chemerin in cardiovascular disease.
Keywords: Chemerin; Coronary artery disease; Metabolic syndrome
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Yu-Jin Hah et al. (2011). Relationship between Chemerin Levels and
Cardiometabolic Parameters and Degree of Coronary
Stenosis in Korean Patients with Coronary Artery
Disease. Diabetes & Metabolism Journal, 35(3), 248–254. doi: 10.4093/dmj.2011.35.3.248
Type
Article
ISSN
2233-6079
DOI
10.4093/dmj.2011.35.3.248
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35570
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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