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Incidence, Risk Factors and Clinical Course of Pancreatic Fluid Collections in Acute Pancreatitis

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Affiliated Author(s)
조광범
Alternative Author(s)
Cho, Kwang Bum
Journal Title
Digestive Diseases and Sciences
ISSN
0163-2116
Issued Date
2014
Abstract
Background Acute pancreatitis is an acute inflammatory
process of the pancreas with variable involvement of other
regional tissues or remote organ systems. Acute fluid collections
and pseudocyst formation are the most frequent
complications of acute pancreatitis.
Aims The aims of this study were to evaluate the incidence,
risk factors, and clinical course of pancreatic fluid
collections and pseudocyst formation following acute
pancreatitis.
Methods A prospective multicenter study was conducted
in five participating centers with 302 patients diagnosed
with acute pancreatitis from January 2011 to July 2012.
Results The incidence of pancreatic fluid collections and
pseudocyst was 42.7 and 6.3 %, respectively. Patients with
fluid collections were significantly younger, compared to
those without fluid collections (51.5 ± 15.9 vs. 60.4 ±
16.5 years, P = 0.000). The proportion of alcoholic etiology
(54.3 %) in patients with fluid collections was significantly
higher compared to other etiologies (P = 0.000). C-reactive
protein (CRP) (48 h) was significantly higher in patients with
fluid collections, compared to patients without fluid collections
(39.2 ± 77.4 vs. 15.1 ± 36.2 mg/dL,P = 0.016).LDH
(48 h) was significantly higher in patients with pseudocyst
formation, compared to patients with complete resolution
(1,317.6 ± 706.4 vs. 478.7 ± 190.5 IU/L, P = 0.000).
Pancreatic fluid collections showed spontaneous resolution in
69.8 % (90/129) and 84.2 % of the pseudocysts disappeared
or decreased in size during follow up.
Conclusions Age, CRP (48 h), and alcohol etiology are
risk factors for pancreatic fluid collections. LDH (48 h)
appears to be a risk factor for pseudocyst formation. Most
pseudocysts showed a decrease in size or spontaneous
resolution with conservative management.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Mei Lan Cui et al. (2014). Incidence, Risk Factors and Clinical Course of Pancreatic Fluid
Collections in Acute Pancreatitis. Digestive Diseases and Sciences, 59(5), 1055–1062. doi: 10.1007/s10620-013-2967-4
Type
Article
ISSN
0163-2116
DOI
10.1007/s10620-013-2967-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35600
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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