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Retrospective Analysis of Clinical and Microbiological Aspects of Klebsiella oxytoca Bacteremia Over a 10-Year Period

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Affiliated Author(s)
김백남
Alternative Author(s)
Kim, Baek Nam
Journal Title
European Journal of Clinical Microbiology and Infectious Diseases
ISSN
0934-9723
Issued Date
2002
Abstract
From 1991 to 2000, 125 sporadic cases of
Klebsiella oxytoca bacteremia were analyzed retrospectively
to review clinical features and to identify the risk
factors associated with resistance to extended-spectrum
cephalosporins and fatal outcome. Bacteremia was acquired
nosocomially in 52% of the patients. Almost all
patients (97%) had an underlying disease, with biliary
and pancreatic disease occurring most frequently (55%).
The biliary tract was the most common site of infection
(44%). Resistance to extended-spectrum cephalosporins
was identified in 22 of the 125 (18%) Klebsiella oxytoca
blood isolates and resistance to ciprofloxacin in 9 (7%).
Only previous antibiotic therapy was strongly associated
with resistance to extended-spectrum cephalosporins in
patients with Klebsiella oxytoca bacteremia (P=0.009).
The mortality rate was 24% and was higher in patients
infected with isolates resistant to extended-spectrum
cephalosporins (41% vs. 20%; P=0.04). In multivariate
analysis, fatal outcome was independently associated
with septic shock, deteriorated mental status, polymicrobial
bacteremia, and solid tumor. Surgical therapy had a
protective effect (OR, 0.06; 95% CI, 0.005–0.7; P=0.03).
In conclusion, Klebsiella oxytoca bacteremia was most
commonly associated with biliary tract infection. Previous
antibiotic therapy was strongly associated with resistance
to extended-spectrum cephalosporins in patients
with Klebsiella oxytoca bacteremia.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
B.N. Kim et al. (2002). Retrospective Analysis of Clinical and Microbiological Aspects
of Klebsiella oxytoca Bacteremia Over a 10-Year Period. European Journal of Clinical Microbiology and Infectious Diseases, 21(6), 419–426. doi: 10.1007/s10096-002-0738-9
Type
Article
ISSN
0934-9723
DOI
10.1007/s10096-002-0738-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35671
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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