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Risk Factors for Penicillin Resistance and Mortality in Korean Adults with Streptococcus pneumoniae Bacteremia

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Affiliated Author(s)
김백남
Alternative Author(s)
Kim, Baek Nam
Journal Title
European Journal of Clinical Microbiology and Infectious Diseases
ISSN
0934-9723
Issued Date
2002
Abstract
A retrospective analysis was performed to
measure the incidence of pneumococcal bacteremia and
to identify risk factors for penicillin resistance and prognostic
factors for outcome in adults. A total of 151 cases
of pneumococcal bacteremia were identified from 149
adults during the period 1996–2000. The overall rate of
penicillin resistance was 49%, ranging from 54.2% in
1996 to 48.5% in 2000 (P=0.93). Rates of resistance to
ceftriaxone, clindamycin, erythromycin, and trimethoprim-
sulfamethoxazole were 21.6%, 51%, 62%, and
44.7%, respectively. Multidrug resistance was documented
in 47.7% of the cases. Penicillin resistance was significantly
associated with solid tumor, biliary drainage catheter,
and previous β-lactam therapy in the univariate analysis.
However, the associations were not as significant as
independent risk factors in the multivariate analysis. Mortality
was 23.8% and did not change significantly during
the study period (P=0.06). Mortality rates in cases caused
by penicillin-susceptible Streptococcus pneumoniae and
penicillin-resistant Streptococcus pneumoniae were 23%
and 24.7%, respectively (P=0.81). Mortality was not significantly
influenced by penicillin resistance, even highlevel
resistance (24.4% vs. 20%; P=0.64). Multivariate
analysis revealed that antineoplastic chemotherapy, respiratory
failure, and acute renal failure were independent
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
B.N. Kim et al. (2002). Risk Factors for Penicillin Resistance and Mortality in Korean Adults
with Streptococcus pneumoniae Bacteremia. European Journal of Clinical Microbiology and Infectious Diseases, 21(1), 35–42. doi: 10.1007/s10096-001-0650-8
Type
Article
ISSN
0934-9723
DOI
10.1007/s10096-001-0650-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35675
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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