α-Lipoic acid inhibits matrix metalloproteinase-9 expression by
inhibiting NF-κB transcriptional activity
- Affiliated Author(s)
- 김혜순; 박근규; 김윤년; 권택규
- Alternative Author(s)
- Kim, Hye Soon; Park, Keun Gyu; Kim, Yoon Nyun; Kwon, Taeg Kyu
- Journal Title
- Experimental and Molecular Medicine.
- ISSN
- 1226-3613
- Issued Date
- 2007
- Abstract
- The migration of vascular smooth muscle cells
(VSMCs) into the intima, an important step in
injury-induced neointimal hyperplasia, requires the
activation of nuclear factor-κB (NF-κB) and the
consequent up-regulation of matrix metalloproteinase-
9 (MMP-9). This study was undertaken to
test for a possible effect of α-lipoic acid (ALA), a
potent inhibitor of NF-κB, on MMP-9 expression. ALA
inhibited high-glucose- and TNF-α-stimulated VSMC
migrations in vitro. It also inhibited high-glucoseand
TNF-α-induced increases in MMP-9 expression.
The activity of MMP-9-promoter constructs with
mutations in the NF-κB binding site was not inhibited
by ALA, indicating an involvement of the NF-κB
signaling pathway in the ALA-specific inhibition of
MMP-9. These data suggest the possibility that ALA
may be useful for the prevention of neointimal hyperplasia
after angioplasty, by inhibiting the NF-κB/
MMP-9 pathway, especially with hyperglycemia.
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